diff --git a/packages/cli-clean/README.md b/packages/cli-clean/README.md
index 2d7364bde..6c32b589f 100644
--- a/packages/cli-clean/README.md
+++ b/packages/cli-clean/README.md
@@ -26,6 +26,8 @@ Cleans caches. Commonly used to ensure build failures are not due to stale cache
 
 Comma-separated flag of caches to clear e.g. `npm,yarn`. If omitted, an interactive prompt will appear. Valid values include `android`, `cocoapods`, `metro`, `npm`, `watchman`, and `yarn`.
 
+On macOS, `cocoapods` removes installed pods from the configured iOS source directory (or `ios` under the project root) and the `.cocoapods` spec cache in your home directory, in addition to running `pod cache clean --all`.
+
 #### `--project-root <string>`
 
 > default: current working directory
diff --git a/packages/cli-clean/src/__tests__/clean.test.ts b/packages/cli-clean/src/__tests__/clean.test.ts
index 022f805ca..761989199 100644
--- a/packages/cli-clean/src/__tests__/clean.test.ts
+++ b/packages/cli-clean/src/__tests__/clean.test.ts
@@ -4,6 +4,7 @@ import prompts from 'prompts';
 import {clean, cleanDir} from '../clean';
 import {cleanup, getTempDirectory, writeFiles} from '../../../../jest/helpers';
 import fs from 'fs';
+import path from 'path';
 
 const DIR = getTempDirectory('temp-cache');
 
@@ -77,4 +78,62 @@ describe('clean', () => {
 
     expect(fs.readdirSync(DIR)).toEqual([]);
   });
+
+  describe('CocoaPods paths', () => {
+    const projectRoot = path.join(DIR, 'project');
+    const homeDirectory = path.join(DIR, 'home');
+    let originalCwd: string;
+
+    beforeEach(() => {
+      originalCwd = process.cwd();
+      writeFiles(DIR, {
+        'project/package.json': '{}',
+        'home/.cocoapods/repos/spec.json': '{}',
+        'working/ios/Pods/keep.txt': 'unrelated project',
+        'working/~/.cocoapods/keep.txt': 'literal tilde directory',
+      });
+      process.chdir(path.join(DIR, 'working'));
+      jest.spyOn(os, 'platform').mockReturnValue('darwin');
+      jest.spyOn(os, 'homedir').mockReturnValue(homeDirectory);
+    });
+
+    afterEach(() => {
+      process.chdir(originalCwd);
+      jest.restoreAllMocks();
+    });
+
+    it('removes the spec cache from the home directory', async () => {
+      await clean([], {project: {}} as any, {
+        include: 'cocoapods',
+        projectRoot,
+      });
+
+      expect(fs.existsSync(path.join(homeDirectory, '.cocoapods'))).toBe(false);
+      expect(fs.existsSync('~/.cocoapods/keep.txt')).toBe(true);
+    });
+
+    it.each([undefined, 'native/ios'])(
+      'removes installed pods from the project with sourceDir %s',
+      async (sourceDir) => {
+        const iosDirectory = path.join(projectRoot, sourceDir ?? 'ios');
+        writeFiles(iosDirectory, {'Pods/cache.txt': 'installed pod'});
+
+        await clean(
+          [],
+          {
+            project: {
+              ios: sourceDir ? {sourceDir: iosDirectory} : null,
+            },
+          } as any,
+          {include: 'cocoapods', projectRoot},
+        );
+
+        expect(fs.existsSync(path.join(iosDirectory, 'Pods'))).toBe(false);
+        expect(fs.existsSync('ios/Pods/keep.txt')).toBe(true);
+        expect(execa).toBeCalledWith('pod', ['cache', 'clean', '--all'], {
+          cwd: projectRoot,
+        });
+      },
+    );
+  });
 });
diff --git a/packages/cli-clean/src/clean.ts b/packages/cli-clean/src/clean.ts
index 943a39525..c01bcf75d 100644
--- a/packages/cli-clean/src/clean.ts
+++ b/packages/cli-clean/src/clean.ts
@@ -126,11 +126,18 @@ export async function clean(
               },
               {
                 label: 'Remove installed CocoaPods',
-                action: () => cleanDir('ios/Pods'),
+                action: () =>
+                  cleanDir(
+                    path.join(
+                      ctx.project.ios?.sourceDir ??
+                        path.join(projectRoot, 'ios'),
+                      'Pods',
+                    ),
+                  ),
               },
               {
                 label: 'Remove CocoaPods spec cache',
-                action: () => cleanDir('~/.cocoapods'),
+                action: () => cleanDir(path.join(os.homedir(), '.cocoapods')),
               },
             ],
           },