diff --git a/src/adcp/decisioning/pg/buyer_agent_registry.py b/src/adcp/decisioning/pg/buyer_agent_registry.py
index 4d8fa2bae..8826f2f6d 100644
--- a/src/adcp/decisioning/pg/buyer_agent_registry.py
+++ b/src/adcp/decisioning/pg/buyer_agent_registry.py
@@ -81,6 +81,7 @@
 import json
 import logging
 import re
+import threading
 from collections.abc import Callable
 from typing import TYPE_CHECKING, Any
 
@@ -171,6 +172,7 @@ def __init__(
         self._pool = pool
         self._table = table_name
         self._mutation_observers: list[MutationObserver] = []
+        self._mutation_observers_lock = threading.Lock()
 
         # Pre-format queries so the hot path doesn't f-string per call.
         # All identifier substitutions are validated at __init__; row
@@ -353,8 +355,32 @@ def add_mutation_observer(self, observer: MutationObserver) -> None:
         mutations propagate to read-side caches without manual
         :meth:`CachingBuyerAgentRegistry.invalidate` calls. See
         :meth:`with_caching` for the bundled pre-wired path.
+
+        Observer registration is thread-safe. Mutations notify a
+        snapshot of the current observer list; observers added or
+        removed while a notification is in flight apply to the next
+        mutation.
+        """
+        with self._mutation_observers_lock:
+            self._mutation_observers.append(observer)
+
+    def remove_mutation_observer(self, observer: MutationObserver) -> bool:
+        """Unregister a mutation observer.
+
+        Returns ``True`` when ``observer`` was registered and removed,
+        ``False`` when it was not present. If the same callback was
+        registered multiple times, one registration is removed per call.
+
+        Removal is thread-safe. Mutations notify a snapshot of the
+        observer list, so removing an observer while a notification is
+        already in flight only affects subsequent mutations.
         """
-        self._mutation_observers.append(observer)
+        with self._mutation_observers_lock:
+            try:
+                self._mutation_observers.remove(observer)
+            except ValueError:
+                return False
+        return True
 
     def with_caching(
         self,
@@ -393,7 +419,9 @@ def with_caching(
 
     def _notify_mutation(self, op: str, agent_url: str) -> None:
         """Fire registered observers; log and swallow exceptions."""
-        for observer in self._mutation_observers:
+        with self._mutation_observers_lock:
+            observers = tuple(self._mutation_observers)
+        for observer in observers:
             try:
                 observer(op, agent_url)
             except Exception:  # noqa: BLE001 — observers must not break mutations
diff --git a/tests/conformance/decisioning/test_pg_buyer_agent_registry.py b/tests/conformance/decisioning/test_pg_buyer_agent_registry.py
index 419e5afaf..8b68440bf 100644
--- a/tests/conformance/decisioning/test_pg_buyer_agent_registry.py
+++ b/tests/conformance/decisioning/test_pg_buyer_agent_registry.py
@@ -339,6 +339,54 @@ def test_add_mutation_observer_fires_on_set_status_and_delete(isolated_pool) ->
     assert calls == [("set_status", "https://obs/"), ("delete", "https://obs/")]
 
 
+def test_remove_mutation_observer_unregisters_callback(isolated_pool) -> None:
+    registry = _registry(isolated_pool)
+    calls: list[tuple[str, str]] = []
+
+    def observer(op: str, url: str) -> None:
+        calls.append((op, url))
+
+    registry.add_mutation_observer(observer)
+    assert registry.remove_mutation_observer(observer) is True
+    assert registry.remove_mutation_observer(observer) is False
+
+    registry.upsert(
+        BuyerAgent(
+            agent_url="https://removed-observer/",
+            display_name="Removed Observer",
+            status="active",
+        )
+    )
+
+    assert calls == []
+
+
+def test_mutation_observer_self_remove_applies_after_current_notification(isolated_pool) -> None:
+    registry = _registry(isolated_pool)
+    calls: list[str] = []
+
+    def self_removing_observer(_op: str, _url: str) -> None:
+        calls.append("self-removing")
+        assert registry.remove_mutation_observer(self_removing_observer) is True
+
+    def persistent_observer(_op: str, _url: str) -> None:
+        calls.append("persistent")
+
+    registry.add_mutation_observer(self_removing_observer)
+    registry.add_mutation_observer(persistent_observer)
+
+    registry.upsert(
+        BuyerAgent(
+            agent_url="https://self-remove-observer/",
+            display_name="Self Remove Observer",
+            status="active",
+        )
+    )
+    registry.set_status("https://self-remove-observer/", "suspended")
+
+    assert calls == ["self-removing", "persistent", "persistent"]
+
+
 def test_observer_exception_does_not_block_mutation(isolated_pool) -> None:
     """An observer raising must not propagate to the mutation caller."""
     registry = _registry(isolated_pool)